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87 A metaanalysis including 20 published articles describing the frequency of the e4 form among people in the United States who had been diagnosed with Alzheimer's dementia found that 56% had one copy of the APOEe4 gene, and 11% had two copies of the APOEe4 gene

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While direct cellular invasion of renal tissue by periodontal pathogens has not been detected in periodontitis, some oral bacteria reportedly invade coronary and aortic endothelial cells (Chou et al., 2005)

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