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Tebartz van Elst L, Maier S, Fangmeier T, Endres D, Mueller GT, Nickel K, et al

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They are about collagen that is disorganized, degraded, or remodeled in a way that reduces tensile strength

A pioneering study found that there was no loss of clonal complexity of tumors that entered a drug-tolerant persister state in response to chemotherapy regimens, and the total CRC cell population possessed an equipotent capacity to enter the persister state rather than just a small subpopulation of cells ( In summary, we studied the characteristics of CRC DTP cells derived from the chemotherapy or targeted agents, and the effects of ferroptosis on persister cells