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Based on extensive clinical trials, the FDA has approved the following medications for quitting tobacco: nicotine replacement therapy (NRT) gum, NRT inhaler, NRT lozenges, NRT nasal spray, NRT patch, varenicline and bupropion

On similar lines, proof-of-concept experiments have demonstrated that Nrf2 (major redox transcription factor) deficient mice developed early and extensive emphysema upon chronic CS exposure for 6 months [93] and worsened the diabetic phenotype in mice [94]

While the intent is to boost revenue, the dramatic tax increase from 99.5 cents per pack to nearly $3 will light up at least one major unintended consequence: cigarette smuggling

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