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Many patients who take colchicine for an extended period of time experience gastrointestinal problems and must discontinue the medication

*Peptides need to be mixed with Bacteriostatic Water before research can be performed

A recent in vitro study showed that PINK1-dependent phosphorylation of Ser111 of Rab8A antagonistically regulates the phosphorylation of Thr72 of Rab8A by LRRK2 (Vieweg et al., 2020), suggesting that there might be even closer crosstalk between the two master kinase