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These canonical functions positioned DHODH primarily as a metabolic enzyme critical for nucleotide biosynthesis and cellular proliferation, before its more recent identification as a mitochondria-specific ferroptosis suppressor in select cancer contexts

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86 , 189,190,191,192,193 Indeed, there is increasing evidence that astrocyte borders around lesions can in fact support regrowing axons, 86,190,194 suggesting that it is time to retire the term glial scar when referring to astroglial borders around CNS tissue lesions