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Drug resistance mechanisms beyond DPP9-NRF2 (255) and AIM2-FOXO3a (258) are also underexploredwhether epigenetic modifications (e.g., DNA methylation of ACSL4), post-translational regulation (e.g., GPX4 ubiquitination), or metabolic rewiring (e.g., alternative antioxidant pathways) drives acquired resistance to ferroptosis inducers requires investigation

Increased activation of oxidase leads to excessive generation of NETs through reactive oxygen species (ROS)/NET reaction cascade

In the skin, Vitamin D synthesis begins with the photolysis of 7-dehydrocholesterol (proVitamin D) in the plasma membrane of keratinocytes, forming preVitamin D [59]

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