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The area under the serum concentration-time curve was increased (152.34 mg/L.h +/- 50.38 s.d.) in cirrhotics compared with normal controls (93.86 mg/L.h +/- 9.60 s.d.) (P 20- or = 2.0 mg/dL and/or estimated glomerular filtration rate or = 25% in the creatinine concentration 48 hours after the procedure (CIN)

its reduction increases antigen exposure, boosts pro-inflammatory signaling, and improves checkpoint blockade efficacy

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Lyophilization removes water from the peptide under carefully controlled conditions, producing a dry powder that is considerably more stable during manufacturing, shipping, and long-term storage than an already dissolved solution