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It can then cause dysfunction of these brain cells, including increasing microvascular endothelial cells permeability, leucocyte adhesion, procoagulant activity, and reducing the availability of nitric oxide through various biochemical pathways initiated by mitochondrial overproduction of reactive oxygen species (124)

Within structured research frameworks, laboratory studies may evaluate receptor-binding characteristics, intracellular signaling cascades, and molecular pathway responses under regulated in vitro and in vivo conditions designed for scientific analysis

And the results speak for themselves

With limited indications, anemia resulting from AZA use is not commonly encountered in clinical practice