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Out of the estimated 55 million children who are wasted, meaning they have a weight-for-height Z score below -2, around 19 million have severe acute malnutrition, which is indicated by a weight-for-height Z score of -3 or below together with edema, or severe wasting, which is indicated by a weight-for-height Z score below -3

Pharmacodynamic analyses confirmed target engagement through suppression of HIF-2regulated gene expression (189)

Untreated pernicious anaemia can cause serious medical issues, which include irreversible damage to the nervous system