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Patients should be reviewed 812 weeks after commencing treatment to assess: Symptomatic improvement, particularly resolution of fatigue and neurological symptoms Haematological response (normalisation of haemoglobin and mean cell volume) Reticulocyte count typically rises within one week, indicating bone marrow response Repeat serum B12 testing is generally not useful after starting parenteral therapy, as levels remain elevated for months

A pilot study demonstrated that supplementation with alpha-linolenic acid, an omega-3 FAs, improved ADHD symptoms [91]

The chromatographic system used a binary solvent (water and methanol) system delivered as a gradient

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