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However, it is possible that granins contribute to airway obstruction in COPD [224] through modulation of inflammation [222] and/or mucus secretion [36]

The DDX3X degrader J10 shows enhanced cytotoxic activity relative to RK-33 In our pursuit of evaluating DDX3X as a therapeutic target in lung cancer, we conceived twelve potential heterobifunctional DDX3X degraders using Proteolysis Targeting Chimeras (PROTACs) technology [44], which leverage the ubiquitin-proteasome system to induce DDX3X degradation (Fig