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No doubt, ROS are a normal byproduct of cellular metabolism, but stress-linked circumstances change the equilibrium between ROS formation and disposal in cellular components of plants [8]

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Sci Rep 6:29240 Ziegler D, Hanefeld M, Ruhnau K, Hasche H, Lobisch M, Schtte K, Kerum G, Malessa R (1999) Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III study)