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5.1 Possible strategies of One-Two Punch therapy The inaugural investigations delving into the potential of this therapeutic strategy surfaced in the year 2017 [135]

Research in naturally aged mice demonstrates measurable improvements in physical performance, with treated animals showing increased running endurance and improved overall fitness metrics compared to untreated aged controls

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This fact was initially implied by the finding that GHRP profoundly stimulated GH release when administered in vivo but not in vitro, where the GH response was very weak