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Ethics statement The animal study was approved by the Institutional Animal Care and Utilization Committee of Nanjing Agricultural University

To clarify the other genotoxicity rather than previously-reported DNA adduct formation, we examined oxidative DNA damage including 8-oxo-7, 8-dihydro-2-deoxyguanosine (8-oxodG) by TAM and its metabolites in the presence of an endogenous reductant and metal ion