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Although we did not find any significant difference between soluble Flt-1, also known as vascular endothelial growth factor receptor 1, levels in the plasma of R and LC patients, LC group exhibits a significant plasma elevation compared to the HC cohort ( Figure 6I )

Further, the methodologies employed for RNA sequencing quantification and read mapping may contribute to an underestimation of biologically relevant signals

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Hepatic ERAD as a circadian and lipogenic regulator The liver represents a major metabolic hub where ERAD intersects with circadian and transcriptional control of metabolism