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This study provides a novel perspective to improve our understanding of the mechanism of HUA-associated LVR and provides important information for pharmacological intervention

The ATM specific kinase inhibitor KU60019 (Tocris, UK) was dissolved in DMSO to 100 mM then diluted to 5 M directly into media

Comprehensive data regarding pharmacokinetics, tissue tolerance, and the effects of this combination on Type I and Type III collagen expression are continuously monitored and collected through clinical study proposals listed on ClinicalTrials.gov, where this combination serves as a key model for the development of future advanced therapies in sports medicine, orthopedics, and traumatology

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