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In general, peptides metabolized by liver enzymes show 1530% longer half-lives in aged populations due to reduced clearance capacity

Int J Biol Macromol 62:287290 Zhong Y et al (2013) Therapeutic use of traditional Chinese herbal medications for chronic kidney diseases

To investigate the severe liver damage and increased mortality observed in hepsin / mice during the early stages after APAP administration, we employed ultra-performance liquid chromatography-tandem mass spectrometry to measure levels of APAP-cysteine adducts in mouse liver tissue, which indirectly assesses the generation of the toxic APAP metabolite, NAPQI (Hairin et al