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254 YanaseK.TsukaharaS.MitsuhashiJ.SugimotoY

When SIRT3 removes acetyl groups from isocitrate dehydrogenase 2 (IDH2), more NADPH gets made in mitochondria

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Preclinical studies have shown that agonists or antagonists of these receptors activated autophagy, thereby enhancing the hosts ability to eliminate M.tb