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Melanotan-II (MT-II), a synthetic peptide known to mimic alpha-melanocyte-stimulating hormone (-MSH) and act as a melanocortin receptor 4 (MC4R) agonist, was the central therapeutic agent explored

They are also used by children with minimal brain dysfunction syndrome [28,29] and patients with encephalopathy [30], and their effect on myalgic encephalomyelitis (chronic fatigue syndrome) has also been tested [31]

In mouse studies, researchers reported improved health markers rather than obvious toxicity, but mouse safety does not predict human safety

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