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Future strategies should prioritize genotype-informed Vitamin D supplementation and integrate metabolic profiling for personalized dose optimization

Regarding MAPK1 and MAPK3, studies have reported that they are involved in BRCA through several approaches, including the activation of cell cycle-related proteins and inhibition of antiapoptotic proteins by MAPK1/MAPK3 phosphorylation, and regulation of cytoskeletal proteins to promote migration 36

This distinction becomes particularly relevant during acute oxidative challenges, in tissues with low enzymatic antioxidant expression, or in individuals with genetic polymorphisms affecting enzyme function

Recent concepts of ovarian carcinogenesis: type I and type II