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Moreover, with the changing concentrations of CDNB or DCNB, from 0.5 mM to 2 mM, the kinetics of the GST-catalyzed reaction remained similar in the reaction system containing GST, glutathione and the inhibitor (F1 peptide or F2 peptide)

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Additionally Asp2 carboxylate is also coordinated near N-terminal Cu(I) ion, which can mediate formation of the in-between state 23

These results suggest that -KG insufficiency induces disulfide stress accumulation and sensitizes human liver and lung cancer cells to glucose starvation