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Those taking tirzepatide, managed an additional 5.5% WL from randomisation, compared to those taking placebo who experienced mean weight regain of 14% from randomisation [49]

Chemically, it is 4-hydroxyphenyl--D-glucopyranoside , a biosynthetic hydroquinone glycoside used in cosmetics because it inhibits tyrosinase, the rate-limiting enzyme in melanin synthesis, as described in this alpha arbutin glossary entry from Cosmacon

PPOX exists within a large protein complex in the mitochondrial inner membrane (the heme metabolon) with other heme synthesis enzymes such as ALAS and FECH, as well as TMEM14C, which plays a role in import of protoporphyrinogen IX into the mitochondrial matrix (Medlock et al., 2015)

Rhonda Patrick: Oh do you