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This 28-day rule comes from United States Pharmacopeia (USP) guidelines for multiple-dose vials containing antimicrobial preservatives

Excess B12 from high oral doses is primarily excreted through urine, which contributes to its low toxicity profile

High temperatures during shipping or prolonged storage above recommended conditions can cause irreversible aggregation

Until governments remove the classification of Prescription Only Medicine from injectable B12, and allow the selling of over-the-counter B12 shots (like in Japan and other countries), well be here to offer this service, and hopefully help you find relief