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104, 105 TLR2 recognizes not only peptidoglycans from Gram-positive bacteria and bacterial lipopeptides, but also endogenous danger signals, such as 70-kDa heat-shock protein (the latter is known to be released in smoke-exposed airways 104 )

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Years later that a twelve-year-old boy fell into a hole of three-hundred-degree heat that opened up before him on Valentine's Day in the backyard of his grandmother's home