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In clinical and in vivo studies, one can assess the effect of switching from cigarette smoking to cMRTP use on exposure responses by measuring biomarkers indicative of these mechanisms

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State Any substance containing or derived from tobacco leaf or nicotine, including, but not limited to cigarettes, cigars, pipe tobacco, snuff, chewing tobacco, dipping tobacco, or any other products prepared from tobacco intended for human consumption in any manner (e.g., smoked, ingested, heated, chewed, absorbed, inhaled, snorted, sniffed)

Under duress from the weight of evidence in its favor, the National Survey on Drug Use and Health report concedes that some of the dramatic decline in smoking among all age groups over the past few years may reflect the use of electronic vaporizing devices (vaping), such as e-cigarettes, as a substitute for delivering nicotine. In the next few weeks, well get new figures on teen vaping from the National Youth Tobacco Survey