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While not highly specific or diagnostic for RA itself, testing for ANA is clinically useful in the differential diagnosis to rule out or identify other systemic rheumatic diseases, such as systemic lupus erythematosus (SLE) or mixed connective tissue disease, which can present with similar joint symptoms (Baker, 2026

In a study evaluating the neuroprotective potential of cynomenine as well as its effect on oxidative stress and inflammation in a rat model of temporal lobe epilepsy induced by intrahippocampal kainate, it was reported that GSH production decreased, ROS and MDA levels increased and Nuclear Factor kappa B (NFB) and Tumour necrosis factor-alpha (TNF-) levels increased [87]

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