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Add to it the appetite suppression and increased focus/concentration/energy and you can see why it is a difficult medication to discontinue. Smoking causes harm to nearly every organ in the body

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Although smoking rates have fallen globally but still smoking is likely to remain a leading cause of preventable death throughout this century unless smoking cessation efforts can significantly and rapidly reduce the number of people who smoke, particularly in the developing countries [128]

The President of the Medical Association in Germany announced, "German women don't smoke"