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The most valuable insights often emerge through careful long-term study rather than rushed short-term approaches

doi: 10.3390/jpm12060977 123 KarrenbauerVDBedriSKHillertJManouchehriniaA

BioMed Pharmacother (2020) 127:110130

Although NGF infusion in the brain showed slight cognitive improvements in AD patients, long-term administration of NGF through ICV was associated with serious side effects, such as hyper-innervation of cerebral blood vessels [47], hypophagia [48] and neuropathic pain [46]