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National Academy Press, Washington DC, 2001

However, chest pain should never be ignored because some underlying causes can be serious and may require urgent medical attention

First of all, our studies delivered a complex aerosol mixture containing a dose of nicotine (039 ng/ml) similar to that commonly observed in the plasma of vapers and smokers 34 , while the studies cited above used pure nicotine at much higher nicotine concentrations (1461460 ng/ml)