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Estrogen activates estrogen receptors in the brain, which function as transcriptional factors and enhance the expression of several neurotransmitters (including glutamate, acetylcholine, serotonin and noradrenaline), and thus stimulate the neuronal circuits required for memory encoding (25)

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While some of his contemporaries who dominated 1970s Hollywood could rightly be considered to have fallen into taking low-effort paycheck gigs in their later years, Hackman didnt slow down for a moment until he unofficially retired post- Mooseport