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27 While head-to-head clinical studies with varenicline have been conducted with the historical cytisine formulation using a 1.5 mg tablet administered in a 25-day downward titration regimen, 2830 no studies, to date, have directly compared varenicline with the novel cytisinicline formulation evaluated in the ORCA program (3 mg tid for 12 weeks), which is currently under regulatory review by the US Food and Drug Administration

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It also: Weakens spinal bones Increases risk of disc prolapse and spinal stenosis Delays healing after spine surgery Doubles the risk of spinal fractures and failed fusions Smokers often need spine surgery a decade earlier than non-smokers and recover much slower