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Therefore, genetic factors such as those can be identified through family history, and other risk factors, including environment pollutions (household and ambient air pollution) and/or epigenetic regulations in response to environmental pollutions, may play important roles in the pathogenesis of COPD in the never-smokers

The results come as states in the United States continue to legalise the drug and health experts, who are increasingly concerned about its impact on lung health, call for more research

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Recent research has found that between 1980 and 2018, menthol cigarettes were responsible for 10.1 million extra smokers, 3 million life years lost, and 378,000 premature deaths