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Comparable results were reported in cholangiocarcinoma (CCA) patients with FGFR alterations, in which erdafitinib achieved a 40.9% ORR in a phase IIa study [414]

718 PGC-1, as a center of energy metabolism and mitochondrial OXPHOS, represents one of the most significant molecules that links the benefits of CR to the improvement of healthy conditions by limiting ROS generation, regulating insulin resistance, and mitochondrial function

When combined with insulin or sulfonylureas, dose adjustments of these medications are frequently necessary to reduce the risk of hypoglycemia, as the glucose-lowering effects may be additive

barbarum s effects on a molecular level, Xia et al