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Funding This study was supported by Grant 81770025 from National Natural Science Foundation of China, Grant ZH2018QNA48 from Cross research funds of Translational Medicine and Grant 2017ZZ02014 from Shanghai key discipline for respiratory diseases

Although some independent studies suggest that heated tobacco users have lower exposure to harmful compounds compared to smokers, this does not match the much lower levels seen in vaping, or quitting altogether [13]

Therefore, those who are mindful of their budget and invest some time in preparation will find that, despite any price differences, both pipe tobacco and rolling tobacco are significantly more cost-effective