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NOS1 is highly expressed in the hippocampus, and selective inhibition of NOS1 can block NO production and inhibit long-term potentiation, affecting cognitive function, particularly working memory [80,81,82]

Robust human RCT data is absent

PRP is generally used for more significant tissue damage (larger tears, more severe tendinopathy, osteoarthritis), while prolotherapy is excellent for ligament laxity and milder tendon issues

Sikiric P, Sever M, Krezic I, Vranes H, Kalogjera L, Smoday IM, Vukovic V, Oroz K, Coric L, Skoro M, Kavelj I, Zubcic S, Sikiric S, Beketic Oreskovic L, Oreskovic I, Blagaic V, Brcic K, Strbe S, Staresinic M, Boban Blagaic A, Skrtic A, Seiwerth S