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Nicotine metabolism Experimental animal studies have shown that nicotine is rapidly metabolized by cytochrome P450 (CYP) in liver, lung, kidney, nasal mucosa, and brain [93]

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Next, we demonstrated that replicating key aspects of the lung alveolar micro-environment specifically, the airliquid interface (ALI), breathing-like motions (stretch), and the inclusion of an immune component significantly enhances the sensitivity of the smoke-induced lung-on-chip model

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