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Specifically, the gene expressions of Interleukin 6 (IL6), Tumor Necrosis Factor Superfamily (TNF), Chemokine (C-C Motif) Ligand 12 (Ccl12), and C-X-C Motif Chemokine Receptor 3 (Cxcr3) were significantly reduced by -6.49 fold (p=0.0048), -2.63 fold (p=0.0227), -2.71 fold (p=0.0146), and -2.28 fold (p=0.0067), respectively, in the e-cig Nic+ group versus the air group (Table 1)

In particular, the RHO GTPase cycle was affected by both types of use