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In addition, dysregulated mitochondrial biogenesis and excessive ATP release under oxidative conditions act as damage-associated molecular patterns (DAMPs), activating inflammasomes and enhancing chemotactic signals for immune cells like CD8 + T cells 67

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The integrated metabolism-immune-neuro interaction model presented in this article may provide a potential comprehensive framework for understanding PEM and highlights the need for a multi-target, collaborative intervention approach that may help disrupt the pathological cycle

Cagrilintide is also being studied in combination with another medication (in a treatment known as CagriSema)