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Amphetamine addiction is characterised by: Consuming Amphetamines over a minimum of 200 days within a 1 year period, according to the DSM-IV criteria [1] A 25% loss of dopamine transporters in the striatum and a 165% increased risk of developing Parkinson's disease [2] [3] Rebound hunger and compulsive skin scratching within 24-72 hours of not taking amphetamines Physical Indicators Of Amphetamine Addiction Rapid Weight Loss A 15kg weight loss within 10 days is a physical indicator of amphetamine addiction because [6]: Noradrenaline levels rise by up to 400% within 45 minutes of drug-taking, increasing resting energy expenditure by over 10% due to the overstimulation of alpha and beta-adrenergic receptors [7] [8] 68.4% experience a reduction in appetite due to the inhibition of hunger signals from the hypothalamus following a 5-fold increase in serotonin within 60 minutes of drug use [8] [9] Daily calorie intake decreases by 24 - 30% after dopamine increases by up to 700% in the striatum, remaining elevated for up to 12 hours and regulating appetite in 22% of users with binge-eating disorder [7] [10] [11] One study found that some amphetamine addicts lose 5kg in weight after not eating for 3 4 days at a time, although some women report gaining between 15 25kg during periods of abstinence [6]

The group was split into two, with one asked to quit on a given day

Darkening of the skin, especially across the knuckles, which has occasionally been the only presenting sign of early B12 deficiency

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