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There is a large body of toxicological, experimental, and epidemiological data, collected since the 1950s, that has established that tobacco use is the largest preventable cause of morbidity and mortality in the world, producing more than 5 million deaths a year

Asia Pacific commanded the largest revenue share of the global duty free cigarette market in 2025, accounting for approximately $3.63 billion or 38.6% of total global revenues

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Diacetyl, a flavoring chemical linked to cases of severe respiratory disease referred to as popcorn lung was found in more than 75% of flavored electronic cigarettes, according to a Harvard Chan School of Public Health study