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The multiple pharmacological treatment options will enhance clinicians ability to identify effective personalised regimens by trying a second medication or combining medications with synergistic or complimentary actions or even escalating treatment to bariatric surgery based on patient preference and underlying comorbidities [7]

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Therefore, targeting the Nrf2/ARE pathway represents a promising strategy to simultaneously address oxidative stress-induced neuronal dysfunction and the toxic proteinopathies characteristic of these disorders, offering hope for more effective treatments that modify disease progression rather than merely alleviating symptoms (Yang et al., 2025

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