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Kulcenty, K., Holysz, M

The math: a high dose of 1,000 mcg yields about 10 mcg of absorbed B12 via passive diffusion alone, safely meeting daily needs before accounting for any direct sublingual absorption

it cannot make a high dose appropriate for a low-substrate body, remove the heart-rate tail in a sensitive person, or guarantee anyone reaches 15 mg in real life

The SURPASS program (for type 2 diabetes) and SURMOUNT program (for obesity) together enrolled over 20,000 participants across multiple Phase III trials