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Its all a matter of personal preference and expanding your knowledge

References World Health Organisation (2018) Noncommunicable diseases country profiles 2018

Cancer Prev Res (Phila) 5:522527 Mehta AJ, Miedinger D, Keidel D, Bettschart R, Bircher A, Bridevaux PO, Curjuric I, Kromhout H, Rochat T, Rothe T, Russi EW, Schikowski T, Schindler C, Schwartz J, Turk A, Vermeulen R, Probst-Hensch N, Kunzli N, Team S (2012) Occupational exposure to dusts, gases, and fumes and incidence of chronic obstructive pulmonary disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults

The only ingredient that isnt completely safe is nicotine, and that is added because its the main reason smokers use cigarettes