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Agm antidepressant effects have been reported to depend upon both imidazoline and GABA receptors, and NMDA-NO axis inhibition (and less consistently between studies, perhaps also serotonin and adrenergic receptors), suggesting a complex ketamine-like rapid antidepressant mechanism that may involve Agm/Glu co-transmission (Uzbay, 2012

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Can vitamin D supplementation reduce nerve pain or other symptoms of peripheral neuropathy, such as numbness and tingling, in people with type 2 diabetes