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Specifically, activation of the TRPA1 receptor could be significant in several pathological situations given that it is known to be stimulated by a multitude of environmental irritants (including constituents of air pollution and burning vegetation), as well as endogenous products of oxidation which can be generated in the airways by inhalation of pollutants or during inflammation (Bessac et al., 2008

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The median levels of both metabolites were about two to four times higher in smokers than non-smokers, indicating that cigarette smoking is a significant source of acrylamide exposure

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