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Common nicotine withdrawal symptoms include: Strong cravings for nicotine Increased anxiety, nervousness, or feeling on edge Irritability, frustration, or mood swings Trouble concentrating or mental fog Sleep problems, including insomnia or disrupted sleep Low mood, sadness, or emotional sensitivity Increased appetite or changes in hunger Fatigue or low energy Headaches or physical tension These symptoms typically peak in the first few days and improve over 34 weeks for most people, though timelines vary

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First, our approach relaxes the log(linear) assumption, using a spline ensemble to estimate the risk 29