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These authors verified that creatine, at doses similar to those detected in plasma after supplementation, had an antioxidant cytoprotective activity on three cell lines against three different oxidative agents: H 2 O 2 , OONO and tert -butylhydroperoxide (tB-OOH)

The lack of a beneficial effect of selenium supplementation was supported in a 2014 meta-analysis of randomized controlled trials (67)