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However, the authors also found that sustained electronic cigarette use predicted an increase in self-reported depression symptoms at 12 months, thereby revealing a bidirectional relationship between depressive symptoms and electronic cigarettes (18)

Only two studies (5%) were longitudinal observational studies 17,20 , while 9 (23%) were cross-sectional studies 14,16,19,21,23,24,30,32,38 , 1 (3%) was a case report 15 , and 27 (69%) were cell/ in vitro or animal studies 18,22,25-29,31,33-37,39-52