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Strength, tolerance, product type, and metabolism can affect rush intensity

A 5mg version was also sold in Japan, but it was soon discontinued

Heated tobacco devices heat up specially-made tobacco sticks to a precise temperature, allowing the adult user to taste the tobacco without having it burn, as it would with a cigarette

The observation that in our cohort only ~ 79% of patients and ~ 82% of probands fulfilled the currently defined minimal criteria for a suspicion of the disease, which require the presence of the combined major criterion 1, indicates that their strict application could lead to a lack of diagnoses