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78 HP 160 CAGRILINTIDE Long-Acting Amylin Analog ALIASES Cagrilintide, AM833, long-acting amylin analog CLASS Synthetic amylin analog once-weekly dual amylin/calcitonin agonist FORMULA CHNO (approx) SEQUENCE 37-residue amylin analog with C20-fatty-acid albumin tether HALF-LIFE ~7 days (once-weekly dosing) ROUTES Subcutaneous (Phase 2/3 clinical) MECHANISM OF ACTION Long-acting amylin analog

CagriSema Dosing Components The CagriSema combination contains: Cagrilintide 2.4 mg (amylin analogue) Semaglutide 2.4 mg (GLP-1 receptor agonist) Both compounds are delivered in a single weekly subcutaneous injection , simplifying administration and improving patient compliance